Transcript
Hi, thank you for tuning in to Penta A 42.42 FM, Andrew here with the latest and greatest in human bodily functions. Today, we’ll be talking about a special hormone that asks, like my favorite fictional character Hamlet, “to pee? or not to pee?”
So Mineralocorticoids are part of the class of steroid hormones and they are heavily involved in controlling the frequency of your pee. They’re pretty much the gatekeepers of awesome. Why and how do they control this you ask? Well, the body needs to be in homeostasis with its sodium levels and the MVP that regulates this amount is the one and only, Mineralocorticoid. It follows a negative feedback loop and determines whether electrolytes such as sodium should be secreted or conserved until the excess leaves on the choo choo train of freedom.This hormone is produced in the cortex of the adrenal gland and, like it’s brothers and sisters in the steroid hormone family, is hydrophobic. Mineralocorticoid is also regulated by two hormones, angiotensin II and andrenocorticotrophic hormone. It is also derived from the lipid, Cholesterol and is therefore, fat soluble but here comes a problem. How can this hormone travel in the bloodstream then? It’s not water soluble and blood is water-based. Well, this clever hormone has a way around that. Mineralocorticoids bind to a serum globulin, a transport protein and the fact that it is fat soluble helps even more in that it is able to enter a cell through its bi lipid fat layer.
Now here’s a fun fact about the Mineralocorticoid, it’s structure, like it’s siblings is very complex compared to other hormones. In fact, it is so complex that it has a half life of around sixty minutes whereas the amino acid based hormone, epinephrine has only a half life of one minute. Also, the name Mineralocorticoid comes from the idea that it controlled the flow of sodium, a mineral. Neat, right?
Well, that’s it for today, tune in next time for another hot topic on the human body system! Stay tuned for some sweet learning about Obama care and why it sucks by our very own conservative republican, Steve.
Citations
http://www.ncbi.nlm.nih.gov/pubmed/10467229
http://www.ncbi.nlm.nih.gov/books/NBK26/box/A517/?report=objectonly
http://www.ncbi.nlm.nih.gov/books/NBK26/
http://en.wikipedia.org/wiki/Mineralocorticoid